Calculate a bootstrapped p-value — bootstrap

This function takes the input data and returns a p-value for the null hypothesis that haplotype configurations which influence coding variant penetrance are not significantly enriched in the population. The p-value is estimated through a bootstrapping procedure, and a confidence interval is returned.

Usage

bootstrap_test(haps, exp_beta = "exp_beta", B = 1000)

Arguments

haps: The output of `characterize_haplotypes`, or another haplotype calling tool. There is one line per haplotype. Must contain the column "beta" and "exp_beta"
exp_beta: The nuame of the column in "haps" that contains the expectation of beta. Defaults to "exp_beta"
B: The number of bootstraps to perform. Default: 1000